Biostability, durability and calcification of cryopreserved human pericardium after rapid glutaraldehyde-stabilization versus multistep ADAPT (R) treatment in a subcutaneous rat model
William Neethling, Christian Brizard, Laura Firth, Ross Glancy
European Journal of Cardio-Thoracic Surgery | OXFORD UNIV PRESS INC | Published : 2014
OBJECTIVES: Autologous pericardium rapidly fixed with glutaraldehyde (GA) in theatre is considered in many cardiac surgery centres the best material currently available for intracardiac, valvular or vascular repair. Implanted non-fixed autologous tissues suffer rapid degeneration, shrinkage and absorption whereas standard xenotypic fixed tissues cause local cytotoxicity and calcification. In the present study, using a subcutaneous rat model, we tested the biostability, durability and calcification potential of four different pericardium patches treated with GA and relevant to current clinical practice. METHODS: Pericardium samples were divided into four groups according to the method of trea..View full abstract
This work was supported by Allied Healthcare Group and Fremantle Heart Institute.