Journal article
Sustained function of genetically modified porcine lungs in an ex vivo model of pulmonary xenotransplantation
GP Westall, BJ Levvey, E Salvaris, J Gooi, S Marasco, F Rosenfeldt, C Egan, R McEgan, M Mennen, P Russell, SC Robson, MB Nottle, KM Dwyer, GI Snell, PJ Cowan
Journal of Heart and Lung Transplantation | ELSEVIER SCIENCE INC | Published : 2013
Abstract
Background Xenotransplantation could provide a solution to the donor shortage that is currently the major barrier to solid-organ transplantation. The ability to breed pigs with multiple genetic modifications provides a unique opportunity to explore the immunologic challenges of pulmonary xenotransplantation. Methods Explanted lungs from wild-type and 3 groups of genetically modified pigs were studied: (i) α1,3-galactosyltransferase gene knockout (GTKO); (ii) GTKO pigs expressing the human complementary regulatory proteins CD55 and CD59 (GTKO/CD55-59); and (iii) GTKO pigs expressing both CD55-59 and CD39 (GTKO/CD55-59/CD39). The physiologic, immunologic and histologic properties of porcine lu..
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Awarded by National Institute of Allergy and Infectious Diseases
Funding Acknowledgements
This study was supported by a Norman E. Shumway International Society for Heart and Lung Transplantation (ISHLT) Career Development Award (to G.W.) and by the Margaret Pratt Foundation.