Dexamethasone Treatment in the First Week of Life for Preventing Bronchopulmonary Dysplasia in Preterm Infants: A Systematic Review
Lex W Doyle, Richard A Ehrenkranz, Henry L Halliday
Neonatology | KARGER | Published : 2010
BACKGROUND: Dexamethasone treatment started soon after birth is controversial. OBJECTIVES: To determine if postnatal dexamethasone treatment during the first week of life is beneficial in preventing bronchopulmonary dysplasia (BPD) in preterm infants. METHODS: Randomised controlled trials of postnatal dexamethasone therapy started in the first week of life in infants at risk of BPD were sought using methods of the Cochrane Collaboration. Data regarding clinical outcomes including mortality, BPD, death or BPD, complications during the primary hospitalisation, and long-term outcome were abstracted and analysed using RevMan 5. RESULTS: 20 randomised controlled trials enrolling a total of 2,860 ..View full abstract
Awarded by National Health and Medical Research Council, Australia
Supported in part by Project Grant No. 108700 from the National Health and Medical Research Council, Australia.