Journal article

Early (< 8 days) postnatal corticosteroids for preventing chronic lung disease in preterm infants

Lex W Doyle, Richard A Ehrenkranz, Henry L Halliday

Cochrane Database of Systematic Reviews | WILEY | Published : 2014

Abstract

BACKGROUND: Chronic lung disease remains a major problem in neonatal intensive care units. Persistent inflammation in the lungs is the most likely underlying pathogenesis. Corticosteroids have been used to either prevent or treat chronic lung disease because of their potent anti-inflammatory effects. OBJECTIVES: To examine the relative benefits and adverse effects of postnatal corticosteroids commenced within the first seven days of life to preterm infants at risk of developing chronic lung disease. SEARCH METHODS: We sought randomised controlled trials (RCTs) of postnatal corticosteroid therapy from the Cochrane Central Register of Controlled Trials (CENTRAL, 2013, Issue 8), MEDLINE (1966 t..

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Grants

Awarded by Eunice Kennedy Shriver National Institute of Child Health and Human Development National Institutes of Health, Department of Health and Human Services, USA


Funding Acknowledgements

Internal sourcesAction Research UK Grant to study the effects of postnatal steroids, UK.Action Research UK Grant to study long-term follow-up, UK.External sourcesNational Health and Medical Research Council, Australia.Eunice Kennedy Shriver National Institute of Child Health and Human Development National Institutes of Health, Department of Health and Human Services, USA.Editorial support of the Cochrane Neonatal Review Group has been funded with Federal funds from the Eunice Kennedy Shriver National Institute of Child Health and Human Development National Institutes of Health, Department of Health and Human Services, USA, under Contract No. HHSN275201100016C