Journal article

The Effects of Enhanced Zinc on Spatial Memory and Plaque Formation in Transgenic Mice

David H Linkous, Paul A Adlard, Patricia B Wanschura, Kathryn M Conko, Jane M Flinn

Journal of Alzheimer's Disease | IOS PRESS | Published : 2009


There is considerable evidence suggesting that metals play a central role in the pathogenesis of Alzheimer's disease. Reports suggest that elevated dietary metals may both precipitate and potentiate an Alzheimer's disease phenotype. Despite this, there remain few studies that have examined the behavioral consequences of elevated dietary metals in wild type and Alzheimer's disease animals. To further investigate this in the current study, two separate transgenic models of AD (Tg2576 and TgCRND8), together with wild type littermates were administered 10 ppm (0.153 mM) Zn. Tg2576 animals were maintained on a zinc-enriched diet both pre- and postnatally until 11 months of age, while TgCRND8 anim..

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Funding Acknowledgements

We are grateful for the support funds from George Mason University and the U. S. Geological Survey, and appreciate the numerous contributions from Dr. Blair F. Jones of the USGS. DHL was supported by a Research Assistantship at George Mason University. PAA is supported by an NH&MRC fellowship. We thank Jun Flores and Katherine Cano for technical assistance. We appreciate the helpful comments of the reviewers of this paper.