Estrogenic Plant Extracts Reverse Weight Gain and Fat Accumulation without Causing Mammary Gland or Uterine Proliferation
Elise F Saunier, Omar I Vivar, Andrea Rubenstein, Xiaoyue Zhao, Moshe Olshansky, Scott Baggett, Richard E Staub, Mary Tagliaferri, Isaac Cohen, Terence P Speed, John D Baxter, Dale C Leitman
PLoS One | PUBLIC LIBRARY SCIENCE | Published : 2011
Long-term estrogen deficiency increases the risk of obesity, diabetes and metabolic syndrome in postmenopausal women. Menopausal hormone therapy containing estrogens might prevent these conditions, but its prolonged use increases the risk of breast cancer, as wells as endometrial cancer if used without progestins. Animal studies indicate that beneficial effects of estrogens in adipose tissue and adverse effects on mammary gland and uterus are mediated by estrogen receptor alpha (ERα). One strategy to improve the safety of estrogens to prevent/treat obesity, diabetes and metabolic syndrome is to develop estrogens that act as agonists in adipose tissue, but not in mammary gland and uterus. We ..View full abstract
Awarded by National Institutes of Health/National Center for Complementary and Alternative Medicine
Awarded by NATIONAL CENTER FOR COMPLEMENTARY &ALTERNATIVE MEDICINE
This work was supported by a grant (1R41AT005575) from the National Institutes of Health/National Center for Complementary and Alternative Medicine. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.OIV and MO have nothing to declare. EFS, AR, SB, RES, MT and IC are employees of Bionovo, Inc. and are stock owners. JDB is a Director and owner of options of Bionovo. JDB and TPS are on the Scientific Advisory Board of Bionovo, Inc. JDB has stock ownership in Karo Bio, A.B., which has commercial interests in this area of research. DCL has received financial support for research from Bionovo, Inc. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.