Tissue-Specific Regulation of Genes by Estrogen Receptors
Dale C Leitman, Sreenivasan Paruthiyil, Chaoshen Yuan, Candice B Herber, Moshe Olshansky, Mary Tagliaferri, Isaac Cohen, Terence P Speed
Seminars in Reproductive Medicine | THIEME MEDICAL PUBL INC | Published : 2012
Estrogens are frequently used in reproductive medicine. The Women's Health Initiative trial found that the risks of menopausal hormone therapy (MHT) exceed the benefits. The estrogens in MHT, however, were introduced prior to our understanding of the mechanism of action of estrogens. Estrogen signaling is highly complex, involving various DNA regulatory elements to which estrogen receptors bind. Numerous transcription factors and co-regulatory proteins modify chromatin structure to further regulate gene transcription. With a greater understanding of estrogen action, the major problem with the current estrogens in MHT appears to be that they are nonselective. This produces beneficial effects ..View full abstract
Sreenivasan Paruthiyil, Isaac Cohen, and Mary Tagliaferri are employees of Bionovo, Inc. Terence P. Speed is on the scientific advisory board of Bionovo, Inc. Dale C. Leitman has received financial support for research from Bionovo, Inc. Chaoshen Yuan, Candice B. Herber, and Moshe Olshansky have nothing to disclose.We thank the National Center for Complementary and Alternative Medicine for funding our research.