Journal article

Ars Moriendi; the art of dying well - new insights into the molecular pathways of necroptotic cell death

James M Murphy, John Silke

EMBO Reports | WILEY | Published : 2014

Abstract

When our time comes to die most people would probably opt for a quick, peaceful and painless exit. But the manner and timing are rarely under our direct control. Hence the Ars moriendi, literally, "The Art of Dying", two texts written in Latin around the 15th century that offered advice on how to die well according to the Christian ideals of the time. In contrast, for individual cells, the death process is frequently under their control and several signaling pathways that cause cell death, including apoptosis, pyroptosis and necroptosis, have been described. Furthermore the manner in which cells die can have good or bad consequences for the organism. In this review we will discuss how cells ..

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Grants

Awarded by NHMRC


Awarded by ARC


Awarded by NHMRC IRIISS


Funding Acknowledgements

JS & JMM are funded by NHMRC grants 541901, 637342 and 1046984 and JMM is funded by an ARC Fellowship FT100100100, with additional support from the Australian Cancer Research Fund, Victorian State Government Operational Infrastructure Support and NHMRC IRIISS grant (361646).