Chloroquine and Its Derivatives Exacerbate B19V-Associated Anemia by Promoting Viral Replication
Claudia Boensch, Christoph Kempf, Ivo Mueller, Laurens Manning, Moses Laman, Timothy ME Davis, Carlos Ros
PLoS Neglected Tropical Diseases | PUBLIC LIBRARY SCIENCE | Published : 2010
BACKGROUND: An unexpectedly high seroprevalence and pathogenic potential of human parvovirus B19 (B19V) have been observed in certain malaria-endemic countries in parallel with local use of chloroquine (CQ) as first-line treatment for malaria. The aims of this study were to assess the effect of CQ and other common antimalarial drugs on B19V infection in vitro and the possible epidemiological consequences for children from Papua New Guinea (PNG). METHODOLOGY/PRINCIPAL FINDINGS: Viral RNA, DNA and proteins were analyzed in different cell types following infection with B19V in the presence of a range of antimalarial drugs. Relationships between B19V infection status, prior 4-aminoquinoline use ..View full abstract
Awarded by National Health and Medical Research Council (NHMRC) of Australia
The clinical studies were supported by funding from MalariaGEN and the National Health and Medical Research Council (NHMRC) of Australia (grant 513782). TMED was supported by an NHMRC Practitioner Fellowship. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.