Reduced Plasmodium vivax Erythrocyte Infection in PNG Duffy-Negative Heterozygotes
Laurin J Kasehagen, Ivo Mueller, Benson Kiniboro, Moses J Bockarie, John C Reeder, James W Kazura, Will Kastens, David T McNamara, Charles H King, Christopher C Whalen, Peter A Zimmerman
PLoS One | PUBLIC LIBRARY SCIENCE | Published : 2007
BACKGROUND: Erythrocyte Duffy blood group negativity reaches fixation in African populations where Plasmodium vivax (Pv) is uncommon. While it is known that Duffy-negative individuals are highly resistant to Pv erythrocyte infection, little is known regarding Pv susceptibility among heterozygous carriers of a Duffy-negative allele (+/-). Our limited knowledge of the selective advantages or disadvantages associated with this genotype constrains our understanding of the effect that interventions against Pv may have on the health of people living in malaria-endemic regions. METHODS AND FINDINGS: We conducted cross-sectional malaria prevalence surveys in Papua New Guinea (PNG), where we have pre..View full abstract
Awarded by National Institutes of Health
Awarded by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
This study was supported by grants from the National Institutes of Health (AI36478-04S1 and AI46919). The funding agency played no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.