Plasma Plasmodium falciparum Histidine-Rich Protein-2 Concentrations Do Not Reflect Severity of Malaria in Papua New Guinean Children
Laurens Manning, Moses Laman, Danielle Stanisic, Anna Rosanas-Urgell, Cathy Bona, David Teine, Peter Siba, Ivo Mueller, Timothy ME Davis
Clinical Infectious Diseases | OXFORD UNIV PRESS INC | Published : 2011
BACKGROUND: In areas of unstable malaria transmission, plasma Plasmodium falciparum histidine-rich protein 2 (PfHRP-2) concentrations parallel total parasite biomass and thus infection severity. However, where transmission is more intense, plasma PfHRP-2 might not reliably predict complications and mortality. METHODS: As part of a prospective case-control study of severe pediatric illness in Madang, Papua New Guinea, we recruited 220 children aged 6 months to 10 years with severe falciparum malaria, 48 with uncomplicated malaria, and 139 healthy controls. Groups were matched by age, sex, and province of parental birth. Plasma PfHRP-2 levels were quantified by validated immunoassay. RESULTS: ..View full abstract
Awarded by National Health and Medical Research Council of Australia
This work was supported by the National Health and Medical Research Council of Australia (513782, scholarship to L.M., and Practitioner Fellowship to T.M.E.D.); the Fogarty Foundation (scholarship to M.L.); the Royal Australasian College of Physicians (Basser scholarship to L.M.).