Journal article
In vitro sensitivity of Plasmodium falciparum to conventional and novel antimalarial drugs in Papua New Guinea
RPM Wong, D Lautu, L Tavul, SL Hackett, P Siba, HA Karunajeewa, KF Ilett, I Mueller, TME Davis
Tropical Medicine and International Health | WILEY | Published : 2010
Abstract
SummaryObjective Recent clinical studies have shown high rates of malaria treatment failure in endemic areas of Papua New Guinea (PNG), necessitating a change of treatment from chloroquine (CQ) or amodiaquine (AQ) plus sulphadoxine-pyrimethamine to the artemisinin combination therapy (ACT) artemether plus lumefantrine (LM). To facilitate the monitoring of antimalarial drug resistance in this setting, we assessed the in vitro sensitivity of Plasmodium falciparum isolates from Madang Province. Methods A validated colorimetric lactate dehydrogenase assay was used to assess growth inhibition of 64 P. falciparum isolates in the presence of nine conventional or novel antimalarial drugs [CQ, AQ, mo..
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Awarded by National Health and Medical Research Council of Australia
Funding Acknowledgements
We are most grateful to Dr Pascal Michon, John Taime, Manasseh Baea, Mak David, the nurses and staff at the PNG Institute of Medical Research at Yagaum, Sister Valsi Kurian and staff at the Alexishafen Health Centre, Michelle England and Dr Jane Allan from the School of Medicine and Pharmacology, University of Western Australia for technical, clinical and/or logistic assistance. This study was supported by the National Health and Medical Research Council of Australia (grant #353663) and the World Health Organisation. TMED is supported by a National Health and Medical Research Council of Australia Practitioner Fellowship.