A Trial of Combination Antimalarial Therapies in Children from Papua New Guinea
Harin A Karunajeewa, Ivo Mueller, Michele Senn, Enmoore Lin, Irwin Law, P Servina Gomorrai, Olive Oa, Suzanne Griffin, Kaye Kotab, Penias Suano, Nandao Tarongka, Alice Ura, Dulcie Lautu, Madhu Page-Sharp, Rina Wong, Sam Salman, Peter Siba, Kenneth F Ilett, Timothy ME Davis
New England Journal of Medicine | MASSACHUSETTS MEDICAL SOC | Published : 2008
BACKGROUND: Malaria control is difficult where there is intense year-round transmission of multiple plasmodium species, such as in Papua New Guinea. METHODS: Between April 2005 and July 2007, we conducted an open-label, randomized, parallel-group study of conventional chloroquine-sulfadoxine-pyrimethamine and artesunate-sulfadoxine-pyrimethamine, dihydroartemisinin-piperaquine, and artemether-lumefantrine in children in Papua New Guinea 0.5 to 5 years of age who had falciparum or vivax malaria. The primary end point was the rate of adequate clinical and parasitologic response at day 42 after the start of treatment with regard to Plasmodium falciparum, after correction for reinfections identi..View full abstract
Awarded by National Health and Medical Research Council of Australia
Supported by grants from the WHO Western Pacific Region, Rotary against Malaria in Papua New Guinea, and the National Health and Medical Research Council of Australia (no. 353663).No potential conflict of interest relevant to this article was reported.We thank Sister Valsi Kurian and the staff of Alexishafen Health Center for their kind cooperation during the study; Sister Maria Goretti, Jovitha Lammey, Wesley Sikuma, Donald Paiva, Bernard (Ben) Maamu, Lena Lorry, Petronilla Wapon, Jane Simbrandu, Merilyn Uranoli, Peter Maku, Moses Lagog, Thomas Adi guma, Jonah Iga, John Taime, Michelle England, Thomas Schulz, and Kaye Baea for clinical, laboratory, database, or logistic assistance; Wendy Davis for help with statistical analysis; and Peter Zimmerman for review of a previous draft of the manuscript.