Journal article
Pharmacokinetic comparison of two piperaquine-containing artemisinin combination therapies in Papua New Guinean children with uncomplicated malaria
S Salman, M Page-Sharp, KT Batty, K Kose, S Griffin, PM Siba, KF Ilett, I Mueller, TME Davis
Antimicrobial Agents and Chemotherapy | Published : 2012
DOI: 10.1128/AAC.06232-11
Abstract
Pharmacokinetic differences between piperaquine (PQ) base and PQ tetraphosphate were investigated in 34 Papua New Guinean children aged 5 to 10 years treated for uncomplicated malaria with artemisinin-PQ (ART-PQ) base or dihydroartemisinin-PQ (DHA-PQ) tetraphosphate. Twelve children received ART-PQ base (two daily doses of 3 mg of ART and 18 mg of PQ base as granules/kg of body weight) as recommended by the manufacturer, with regular clinical assessment and blood sampling over 56 days. PQ concentrations in plasma samples collected from 22 children of similar ages with malaria in a previously published pharmacokinetic study of DHA-PQ tetraphosphate (three daily doses of 2.5 mg of ART and 20 m..
View full abstractGrants
Awarded by National Health and Medical Research Council (NHMRC) of Australia
Funding Acknowledgements
The National Health and Medical Research Council (NHMRC) of Australia funded the study (grant 634343). T.M.E.D. is supported by an NHMRC Practitioner Fellowship.