Journal article
Artemisinin-naphthoquine combination therapy for uncomplicated pediatric malaria: A tolerability, safety, and preliminary efficacy study
J Benjamin, B Moore, ST Lee, M Senn, S Griffin, D Lautu, S Salman, P Siba, I Mueller, TME Davis
Antimicrobial Agents and Chemotherapy | Published : 2012
DOI: 10.1128/AAC.06248-11
Abstract
Artemisinin-naphthoquine (ART-NQ) is a fixed-dose coformulated antimalarial therapy recommended as a single-dose treatment and marketed in Papua New Guinea among other tropical countries. We conducted a tolerability, safety, and efficacy study of ART-NQ for Papua New Guinean children aged 5 to 12 years with uncomplicated malaria, comparing single-dose ART-NQ (15 and 6 mg/kg of body weight) given with water (group 1; n = 15), single-dose ART-NQ (22 and 9 mg/kg) given with milk (group 2; n = 17), or two daily doses of 22 and 9 mg/kg given with water (group 3; n = 16). Of the 48 children (45 with Plasmodium falciparum malaria, 2 with Plasmodium vivax malaria, and 1 with mixed-species malaria), ..
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Awarded by National Health and Medical Research Council (NHMRC) of Australia
Funding Acknowledgements
This study was funded by the National Health and Medical Research Council (NHMRC) of Australia (grant 634343). S.T.L. was the recipient of a Cranmore Undergraduate Scholarship through the Faculty of Medicine, Dentistry, and Health Science, University of Western Australia, and T.M.E.D. is supported by an NHMRC Practitioner Fellowship.