Journal article

Naturally Acquired Immune Responses to P. vivax Merozoite Surface Protein 3 alpha and Merozoite Surface Protein 9 Are Associated with Reduced Risk of P. vivax Malaria in Young Papua New Guinean Children

Danielle I Stanisic, Sarah Javati, Benson Kiniboro, Enmoore Lin, Jianlin Jiang, Balwan Singh, Esmeralda VS Meyer, Peter Siba, Cristian Koepfli, Ingrid Felger, Mary R Galinski, Ivo Mueller

PLoS Neglected Tropical Diseases | PUBLIC LIBRARY SCIENCE | Published : 2013

Abstract

BACKGROUND: Plasmodium vivax is the most geographically widespread human malaria parasite. Cohort studies in Papua New Guinea have identified a rapid onset of immunity against vivax-malaria in children living in highly endemic areas. Although numerous P. vivax merozoite antigens are targets of naturally acquired antibodies, the role of many of these antibodies in protective immunity is yet unknown. METHODOLOGY/PRINCIPAL FINDINGS: In a cohort of children aged 1-3 years, antibodies to different regions of Merozoite Surface Protein 3α (PvMSP3α) and Merozoite Surface Protein 9 (PvMSP9) were measured and related to prospective risk of P. vivax malaria during 16 months of active follow-up. Overall..

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Funding Acknowledgements

This work was supported by the National Institutes of Health (AI063135), the Australian Agency for International Development (AusAID) and the National Health and Medical Research Council (Grant no. 516735). IM is supported by an NHMRC Senior Research Fellowship (Grant no. 1043345). This work was made possible through Victorian State Government Operational Infrastructure Support and Australian Government NHMRC IRIISS. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.