Population Pharmacokinetics of Artemether, Lumefantrine, and Their Respective Metabolites in Papua New Guinean Children with Uncomplicated Malaria
Sam Salman, Madhu Page-Sharp, Susan Griffin, Kaye Kose, Peter M Siba, Kenneth F Ilett, Ivo Mueller, Timothy ME Davis
Antimicrobial Agents and Chemotherapy | AMER SOC MICROBIOLOGY | Published : 2011
There are sparse published data relating to the pharmacokinetic properties of artemether, lumefantrine, and their active metabolites in children, especially desbutyl-lumefantrine. We studied 13 Papua New Guinean children aged 5 to 10 years with uncomplicated malaria who received the six recommended doses of artemether (1.7 mg/kg of body weight) plus lumefantrine (10 mg/kg), given with fat over 3 days. Intensive blood sampling was carried out over 42 days. Plasma artemether, dihydroartemisinin, lumefantrine, and desbutyl-lumefantrine were assayed using liquid chromatography-mass spectrometry or high-performance liquid chromatography. Multicompartmental pharmacokinetic models for a drug plus i..View full abstract
Awarded by National Health and Medical Research Council (NHMRC) of Australia
The National Health and Medical Research Council (NHMRC) of Australia funded the study (grant 634343). T. M. E. D. is supported by an NHMRC Practitioner Fellowship.