Journal article
Distinct distribution of killer-cell immunoglobulin-like receptor genes in the Mugil and Ilaita areas of Papua New Guinea
E John, FT Christiansen, I Mueller, L Schofield, D Senitzer, P Siba, CS Witt
Tissue Antigens | WILEY-BLACKWELL | Published : 2012
Abstract
The frequency of the killer-cell immunoglobulin-like receptor (KIR) genes and transmembrane alleles of KIR2DL4 were studied in coastal (Mugil community) and inland (Ilaita community) communities in Papua New Guinea. Linkage disequilibria between KIR genes and between alleles of KIR2DL4 and the KIR genes were similar to those found in other populations suggesting conservation of the usual gene order in Papua New Guinean haplotypes. Significant differences in the frequency of KIR genes were found between the two populations despite being separated by only 300 km. Examples of individuals who lacked the KIR2DL4 gene and others whose KIR2DL4 allele appeared to have 11 adenines in the polyadenine ..
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Awarded by National Institute of Allergy and Infectious Diseases
Funding Acknowledgements
This work was supported by grants (516735 and 637406) from the National Health and Medical Research Foundation. Infrastructure was supported by the Victorian State Government OIS and NHMRC IRIISS grants. LS is an International Research Scholar of the Howard Hughes Medical Institute. We would like to thank the IMR field teams, in particular Pascal Michon, Livingstone Tavul, Elija Dabod, Enmoore Lin and Benson Kiniboro, the study participants, their parents and guardians and the staff of the Mugil and Ilaita Health centres for the collection of the sample used for this study. The Ilaita study was supported by funding from the National Institute of Health (AI063135) and the Australian Agency for International Development.