Journal article

Silencing and Nuclear Repositioning of the lambda 5 Gene Locus at the Pre-B Cell Stage Requires Aiolos and OBF-1

Alexander Karnowski, Chun Cao, Gabriele Matthias, Sebastian Carotta, Lynn M Corcoran, Inga-Lill Martensson, Jane A Skok, Patrick Matthias

PLOS ONE | PUBLIC LIBRARY SCIENCE | Published : 2008

Abstract

The chromatin regulator Aiolos and the transcriptional coactivator OBF-1 have been implicated in regulating aspects of B cell maturation and activation. Mice lacking either of these factors have a largely normal early B cell development. However, when both factors are eliminated simultaneously a block is uncovered at the transition between pre-B and immature B cells, indicating that these proteins exert a critical function in developing B lymphocytes. In mice deficient for Aiolos and OBF-1, the numbers of immature B cells are reduced, small pre-BII cells are increased and a significant impairment in immunoglobulin light chain DNA rearrangement is observed. We identified genes whose expressio..

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University of Melbourne Researchers