IS THERE A DOSE RESPONSE RELATIONSHIP BETWEEN WEIGHT LOSS AND SYMPTOM IMPROVEMENT IN PERSONS WITH SYMPTOMATIC KNEE OSTEOARTHRITIS?

Abstract

OBJECTIVE: We examined the dose-response relationship between weight reduction and pain/functional improvement in persons with symptomatic knee osteoarthritis (KOA) participating in a community-based weight loss program. METHODS: Consecutive participants with KOA and enrolled in the 18-week Osteoarthritis Healthy Weight for Life weight-loss program were selected. In this completer-type analysis, participants were assessed at baseline, 6 weeks, and 18 weeks for body weight and Knee Injury and Osteoarthritis Outcome Score (KOOS) subscales. The dose-response relationship between weight-change categories (>10%, 7.6-10%, 5.1-7.5%, 2.6-5.0%, and 2.5% reduction in body weight. There was a significa..