Journal article

Mucosal antigen primes diabetogenic cytotoxic T-Lymphocytes regardless of dose or delivery route

A Hanninen, A Braakhuis, WR Heath, LC Harrison

Diabetes | AMER DIABETES ASSOC | Published : 2001


Administration of antigens via mucosal routes, such as orally or intranasally, can induce specific immunological tolerance and has been used as a rational basis for the treatment of autoimmune diseases, including type 1 diabetes. Recently, however, orally delivered antigens were shown to induce CD8 cytotoxic T-lymphocytes (CTLs) capable of causing autoimmune diabetes. In this report, we have examined several mucosal routes for their ability to induce CTLs and autoimmune diabetes, with the aim of identifying approaches that would maximize tolerance and minimize CTL generation. In normal C57BL/6 mice, ovalbumin (OVA) delivered by either the oral or nasal routes or by aerosol inhalation was abl..

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