Protein export in malaria parasites: an update
Brendan Elsworth, Brendan S Crabb, Paul R Gilson
Cellular Microbiology | WILEY | Published : 2014
Symptomatic malaria is caused by the infection of human red blood cells (RBCs) with Plasmodium parasites. The RBC is a peculiar environment for parasites to thrive in as they lack many of the normal cellular processes and resources present in other cells. Because of this, Plasmodium spp. have adapted to extensively remodel the host cell through the export of hundreds of proteins that have a range of functions, the best known of which are virulence-associated. Many exported parasite proteins are themselves involved in generating a novel trafficking system in the RBC that further promotes export. In this review we provide an overview of the parasite synthesized export machinery as well as rece..View full abstract
Our work is supported by grants from the Australian National Health and Medical Research Council. The authors gratefully acknowledge the contribution of the Victorian Operational Infrastructure Support Program and the NHMRC IRIISS scheme. BE was supported by an Australian Postgraduate Award.