Journal article

CD1d-restricted NKT cells contribute to malarial splenomegaly and enhance parasite-specific antibody responses

DS Hansen, MA Siomos, T de Koning-Ward, L Buckingham, BS Crabb, L Schofield

European Journal of Immunology | WILEY-V C H VERLAG GMBH | Published : 2003


CD1d-restricted NKT cells are a novel T cell lineage with unusual features. They co-express some NK cell receptors and recognize glycolipid antigens through an invariant T cell receptor (TCR) in the context of CD1d molecules. Upon activation through the TCR, NKT cells produce large amounts of IFN-gamma and IL-4. It has been proposed that rapid cytokine output by activated NKT cells may induce bystander activation of other lymphoid lineages. The impact of CD1d-restricted NKT cell activation in the induction of B cell-mediated immune responses to infection is still unclear. We show here that CD1-restricted NKT cells contribute to malarial splenomegaly associated with expansion of the splenic B..

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