Journal article

beta-catenin negatively regulates expression of the prostaglandin transporter PGT in the normal intestinal epithelium and colorectal tumour cells: a role in the chemopreventive efficacy of aspirin?

HJM Smartt, A Greenhough, P Ordonez-Moran, M Al-Kharusi, TJ Collard, JM Mariadason, J Huelsken, AC Williams, C Paraskeva

British Journal of Cancer | NATURE PUBLISHING GROUP | Published : 2012


BACKGROUND: Levels of the pro-tumorigenic prostaglandin PGE(2) are increased in colorectal cancer, previously attributed to increased synthesis through COX-2 upregulation and, more recently, to decreased catabolism. The functionally linked genes 15-prostaglandin dehydrogenase (15-PGDH) and the prostaglandin transporter PGT co-operate in prostaglandin degradation and are downregulated in colorectal cancer. We previously reported repression of 15-PGDH expression by the Wnt/β-catenin pathway, commonly deregulated during early colorectal neoplasia. Here we asked whether β-catenin also regulates PGT expression. METHODS: The effect of β-catenin deletion in vivo was addressed by PGT immunostaining ..

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University of Melbourne Researchers