Genetics of vasovagal syncope
Karl Martin Klein, Samuel F Berkovic
AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL | ELSEVIER | Published : 2014
INTRODUCTION: Vasovagal syncope (VVS) is the most frequent type of syncope and affects about 25% of the population. The role of genetic factors in VVS has long been debated. In this review we will discuss the current evidence that strongly suggests a major genetic component. CLINICAL GENETIC STUDIES: Family aggregation studies have consistently shown that individuals with VVS more frequently have affected family members with VVS than unaffected controls. Clear evidence for the relevance of genetic factors was provided by a twin study that showed significantly higher concordance rates in monozygous compared to dizygous twins for frequent syncope and syncope associated with typical vasovagal t..View full abstract
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Awarded by Deutsche Forschungsgemeinschaft
Awarded by NHMRC Program Grant
KMK was supported by a research fellowship from the Deutsche Forschungsgemeinschaft [KL 2254/1-1] and a scholarship from The University of Melbourne. SFB was supported by an NHMRC Australia Fellowship and an NHMRC Program Grant (ID: 628952).