Journal article

Suppressors of cytokine signaling (SOCS): negative regulators of signal transduction

WS Alexander, R Starr, D Metcalf, SE Nicholson, A Farley, AG Elefanty, M Brysha, BT Kile, R Richardson, M Baca, JG Zhang, TA Willson, EM Viney, NS Sprigg, S Rakar, J Corbin, S Mifsud, L DiRago, D Cary, NA Nicola Show all



SOCS-1 was originally identified as an inhibitor of interleukin-6 signal transduction and is a member of a family of proteins (SOCS-1 to SOCS-7 and CIS) that contain an SH2 domain and a conserved carboxyl-terminal SOCS box motif. Mutation studies have established that critical contributions from both the amino-terminal and SH2 domains are essential for SOCS-1 and SOCS-3 to inhibit cytokine signaling. Inhibition of cytokine-dependent activation of STAT3 occurred in cells expressing either SOCS-1 or SOCS-3, but unlike SOCS-1, SOCS-3 did not directly interact with or inhibit the activity of JAK kinases. Although the conserved SOCS box motif appeared to be dispensable for SOCS-1 and SOCS-3 actio..

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