5-HT-2B receptor

Abstract

The 5-HT 2B receptor mediates fundic smooth muscle contraction. It was difficult to characterize pharmacologically, due to operational features similar to those of other members of the 5-HT 2 family. Eventually, the cloning of the rat, mouse, and human 'fundic' receptors (also known as 5-HT 2F) clarified the issue. It is located on human chromosome 2q36.3-2q37.1. 5-HT 2B receptor mRNA is found in rat fundus, gut, heart, kidney, lung, and brain. Centrally, 5-HT 2B receptor-like immunoreactivity is restricted to cerebellum, lateral septum, hypothalamus, and medial amygdala. Application of BW 723C86 into the medial amygdala produces anxiolytic properties in rat social interactions. 5-HT 2B rece..