Piezo2 Expression in Corneal Afferent Neurons
Romke Bron, Rhiannon J Wood, James A Brock, Jason J Ivanusic
The Journal of Comparative Neurology | WILEY-BLACKWELL | Published : 2014
Recently, a novel class of mechanically sensitive channels has been identified and have been called Piezo channels. In this study, we explored Piezo channel expression in sensory neurons supplying the guinea pig corneal epithelium, which have well-defined modalities in this species. We hypothesized that a proportion of corneal afferent neurons express Piezo2, and that these neurons are neurochemically distinct from corneal polymodal nociceptors or cold-sensing neurons. We used a combination of retrograde tracing to identify corneal afferent neurons and double label in situ hybridization and/or immunohistochemistry to determine their molecular and/or neurochemical profile. We found that Piezo..View full abstract
Grant sponsor: Development grant from the Department of Anatomy and Neuroscience, University of Melbourne.