Journal article
Radiosynthesis of a novel PET fluoronicotinamide for melanoma tumour PET imaging; [18F]MEL050
I Greguric, S Taylor, T Pham, N Wyatt, CD Jiang, T Bourdier, C Loc'H, P Roselt, OC Neels, A Katsifis
Australian Journal of Chemistry | CSIRO PUBLISHING | Published : 2011
DOI: 10.1071/CH11048
Abstract
[18F]6-Fluoro-N-[2-(diethylamino)ethyl]nicotinamide [ 18F]MEL050 is a novel nicotinamide-based radiotracer, designed to target random metastatic dissemination of melanoma tumours by targeting melanin. Preclinical studies suggest that [18F]MEL050 has an excellent potential to improve diagnosis and staging of melanoma. Here we report the radiochemical optimization conditions of [18F]MEL050 and its large scale automated synthesis using a GE FXFN automated radiosynthesis module for clinical, phase-1 investigation. [18F]MEL050 was prepared via a one-step synthesis using no-carrier added K[18F]F-Krytpofix® 222 (DMSO, 170°C, 5min) followed by HPLC purification. Using 6-chloro-N-[2- (diethylamino)et..
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Funding Acknowledgements
The authors gratefully acknowledge Tim Jackson for technical assistance. We thank the Commonwealth Government of Australia for their financial support to the Collaborative Research Centre for Biomedical Imaging Development.