Journal article

RNA interference and potential therapeutic applications of short interfering RNAs

TC Karagiannis, A El-Osta

Cancer Gene Therapy | NATURE PUBLISHING GROUP | Published : 2005

Abstract

RNA interference is an endogenous gene-silencing mechanism that involves double-stranded RNA-mediated sequence-specific mRNA degradation. The discovery of this pathway together with the elucidation of the structure and function of short interfering RNAs--the effector molecules of RNA interference--has had an enormous impact on experimental biology. RNA interference technologies are currently the most widely utilized techniques in functional genomic studies. Furthermore, there is an intense research effort aimed at developing short interfering RNAs for therapeutic purposes. A number of proof-of-principle experiments have demonstrated the clinical potential of appropriately designed short inte..

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University of Melbourne Researchers