Chromatin context and ncRNA highlight targets of MeCP2 in brain
Scott S Maxwell, Gregory J Pelka, Patrick PL Tam, Assam El-Osta
RNA BIOLOGY | TAYLOR & FRANCIS INC | Published : 2013
The discovery that Rett syndrome (RTT) is caused by mutation of the methyl-CpG-binding-protein MeCP2 provided a major breakthrough in understanding the neurodevelopmental disorder and accelerated MeCP2 research. However, gene regulation by MeCP2 is complicated. The current consensus for MeCP2 remains as a classical repressor complex, with major emphasis on its role in methylation-dependent binding and repression. However, recent evidence indicates additional regulatory roles, suggesting non-classical mechanisms in gene activation. This has opened the field of MeCP2 research and suggests that the gene targets may not be the usual suspects, that is, dependent only on DNA methylation. Here we e..View full abstract
The authors acknowledge grant and fellowship support from the National Health and Medical Research Council (NHMRC). Maxwell S was supported by a Postgraduate Research Scholarship and Pelka G by a Biomedical (Peter Doherty) Fellowship. Tam PPL is a Senior Principal Research Fellow and El-Osta A is a Senior Research Fellow of the NHMRC. Our work is supported in part by the Victorian Government's Operational Infrastructure Support Program and Mr James Fairfax.