Double-strand breaks and the concept of short- and long-term epigenetic memory
Christian Orlowski, Li-Jeen Mah, Raja S Vasireddy, Assam El-Osta, Tom C Karagiannis
Chromosoma | SPRINGER | Published : 2011
Double-strand breaks represent an extremely cytolethal form of DNA damage and thus pose a serious threat to the preservation of genetic and epigenetic information. Though it is well-known that double-strand breaks such as those generated by ionising radiation are among the principal causative factors behind mutations, chromosomal aberrations, genetic instability and carcinogenesis, significantly less is known about the epigenetic consequences of double-strand break formation and repair for carcinogenesis. Double-strand break repair is a highly coordinated process that requires the unravelling of the compacted chromatin structure to facilitate repair machinery access and then restoration of t..View full abstract
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Awarded by National Health and Medical Research Council of Australia
The support of the Australian Institute of Nuclear Science and Engineering is acknowledged. TCK was the recipient of AINSE awards. Epigenomic Medicine Lab is supported by the National Health and Medical Research Council of Australia (566559). This work is funded by the CRC for Biomedical Imaging Development Ltd, established and supported under the Australian Government's Cooperative Research Centres (CRC) program. CO and LM are supported by Melbourne Research (University of Melbourne) and Australian Postgraduate Awards, respectively, and Biomedical Imaging CRC supplementary scholarships.