Epigenetic and Genetic Mechanisms of Abnormal 11p15 Genomic Imprinting in Silver-Russell and Beckwith-Wiedemann Syndromes
J Demars, Y Le Bouc, A El-Osta, C Gicquel
Current Medicinal Chemistry | BENTHAM SCIENCE PUBL LTD | Published : 2011
Fetal growth is a complex process depending on the genetics of the fetus, the availability of nutrients to the fetus, maternal nutrition and various growth factors and hormones of maternal, fetal and placental origin. The IGF system, and more particularly IGF2, is one of the most important endocrine and paracrine growth systems regulating fetal and placental growth (reviewed in ). The IGF2 gene is regulated by genomic imprinting and is expressed only from the paternally-inherited allele in most tissues during fetal development and after birth. Imprinted genes are tightly regulated and are therefore particularly susceptible to changes, including environmental and nutritional changes. Dysre..View full abstract
Awarded by National Health and Medical Research Council of Australia
Awarded by Institut National de la Sante et de la Recherche Medicale
This work was supported by the National Health and Medical Research Council of Australia (Project grant 472637), the Baker IDI Heart and Diabetes Institute and the Institut National de la Sante et de la Recherche Medicale UMR-S938.