Glycemic Memories and the Epigenetic Component of Diabetic Nephropathy
Samuel T Keating, Assam El-Osta
Current Diabetes Reports | CURRENT MEDICINE GROUP | Published : 2013
A strong case for the deregulation of epigenetic chromatin modifications in the development and progression of various chronic complications of diabetes has emerged from recent experimental observations. Clinical trials of type 1 and type 2 diabetes patients highlight the importance of early and intensive treatment and the prolonged damage of hyperglycemia on organs such as the kidney. The functional relationship between the regulation of chromatin architecture and persistent gene expression changes conferred by prior hyperglycemia represents an important avenue of investigation for explaining diabetic nephropathy. While several studies implicate epigenetic changes at the chromatin template ..View full abstract
The authors acknowledge grant, scholarship, and fellowship support from the National Health and Medical Research Council (NHMRC), the Diabetes Australia Research Trust (DART), the Juvenile Diabetes Research Foundation International (JDRF), the National Heart Foundation of Australia (NHF), and the Australian Postgraduate Award (APA). A. E-O is a Senior Research Fellow supported by the NHMRC. This article was supported in part by the Victorian Government's Operational Infrastructure Support Program.