Journal article

Chromatin modifying agents - the cutting edge of anticancer therapy

Faith AA Kwa, Aneta Balcerczyk, Paul Licciardi, Assam El-Osta, Tom C Karagiannis

Drug Discovery Today | ELSEVIER SCI LTD | Published : 2011

Abstract

Chromatin modifying compounds are emerging as the next generation of anticancer therapies. By altering gene expression they could be able to correct uncontrolled proliferation and, in certain cases, aberrant apoptotic pathways, which are hallmarks of malignant cells. The modulation of gene expression is regulated via chromatin remodelling processes that include DNA methylation and chromatin modifications. The identification of aberrant methylation of genes and dysregulated histone acetylation status in cancer cells provides a basis for novel epigenetic therapies. Currently available chromatin modifying agents, a group that includes DNA methyltransferase and histone deacetylase inhibitors, ex..

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University of Melbourne Researchers