Journal article

CDT, GGT, and AST as markers of alcohol use: The WHO/ISBRA Collaborative Project

KM Conigrave, LJ Degenhardt, JB Whitfield, JB Saunders, A Helander, B Tabakoff

Alcoholism Clinical and Experimental Research | LIPPINCOTT WILLIAMS & WILKINS | Published : 2002


BACKGROUND: Estimates of the performance of carbohydrate deficient transferrin (CDT) and gamma glutamyltransferase (GGT) as markers of alcohol consumption have varied widely. Studies have differed in design and subject characteristics. The WHO/ISBRA Collaborative Study allows assessment and comparison of CDT, GGT, and aspartate aminotransferase (AST) as markers of drinking in a large, well-characterized, multicenter sample. METHODS: A total of 1863 subjects were recruited from five countries (Australia, Brazil, Canada, Finland, and Japan). Recruitment was stratified by alcohol use, age, and sex. Demographic characteristics, alcohol consumption, and presence of ICD-10 dependence were recorded..

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