Deregulated cell death and lymphocyte homeostasis cause premature lethality in mice lacking the BH3-only proteins Bim and Bmf
Verena Labi, Claudia Woess, Selma Tuzlak, Miriam Erlacher, Philippe Bouillet, Andreas Strasser, Alexandar Tzankov, Andreas Villunger
Blood | AMER SOC HEMATOLOGY | Published : 2014
BH3 domain-only proteins (BH3-only) proteins are members of the Bcl-2 family that play crucial roles in embryogenesis and the maintenance of tissue homeostasis by triggering apoptotic cell death. The BH3-only protein Bim is critical for developmental apoptosis of lymphocytes, securing establishment of tolerance and for the termination of immune responses. Bim is believed to act in concert with other BH3-only proteins or members of the tumor necrosis factor receptor family in getting rid of unwanted cells. Bmf, a related BH3-only protein, was shown to play a role in B-cell homeostasis and to mediate cell death in response to certain apoptotic triggers, including glucocorticoid, histone deacet..View full abstract
Awarded by Austrian Science Fund
Awarded by Austrian Science Fund (FWF)
This work was supported by Austrian Science Fund grants P23510-B19 and Y212-B13 (to A.V.), the National Health and Medical Research Council Australia, Leukemia and Lymphoma Society (Specialized Center of Research grant) and the Cancer Council of Victoria (A.S. and P.B.), the Tyrolean Science Fund (V. L.), and "Osterreichische Krebshilfe-Tirol" (V.L. and C.W.). C.W. was supported by a Doc-fFORTE doctoral fellowship from the Austrian Academy of Science.