Journal article
Optimal mean airway pressure during high-frequency oscillatory ventilation determined by measurement of respiratory system reactance
E Zannin, ML Ventura, RL Dellacà, M Natile, P Tagliabue, EJ Perkins, M Sourial, R Bhatia, PA Dargaville, DG Tingay
Pediatric Research | Published : 2014
DOI: 10.1038/pr.2013.251
Abstract
Background: The aims of the present study were (i) to characterize the relationship between mean airway pressure (PAW) and reactance measured at 5 Hz (reactance of the respiratory system (XRS), forced oscillation technique) and (ii) to compare optimal PAW (P opt) defined by XRS, oxygenation, lung volume (V L), and tidal volume (VT) in preterm lambs receiving high-frequency oscillatory ventilation (HFOV). Methods: Nine 132-d gestation lambs were commenced on HFOV at PAW of 14 cmH2O (P start). PAW was increased stepwise to a maximum pressure (Pmax) and subsequently sequentially decreased to the closing pressure (Pcl, oxygenation deteriorated) or a minimum of 6 cmH 2O, using an oxygenation-base..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
D.G.T. is supported by a National Health and Medical Research Council Clinical Research Fellowship (Australia, grant ID 491286). D.G.T., E.J.P., and R.B. are supported by the Victorian Government Operational Infrastructure Support Program (Victoria, Australia). M.N. and M.L.V. are supported by a grant from Fondazione MBBM (Monza, Italy).