Journal article

Optimal mean airway pressure during high-frequency oscillatory ventilation determined by measurement of respiratory system reactance

Emanuela Zannin, Maria Luisa Ventura, Raffaele L Dellaca, Miria Natile, Paolo Tagliabue, Elizabeth J Perkins, Magdy Sourial, Risha Bhatia, Peter A Dargaville, David G Tingay

Pediatric Research | NATURE PUBLISHING GROUP | Published : 2014


BACKGROUND: The aims of the present study were (i) to characterize the relationship between mean airway pressure (PAW) and reactance measured at 5 Hz (reactance of the respiratory system (X RS), forced oscillation technique) and (ii) to compare optimal PAW (P opt) defined by X RS, oxygenation, lung volume (VL), and tidal volume (VT) in preterm lambs receiving high-frequency oscillatory ventilation (HFOV). METHODS: Nine 132-d gestation lambs were commenced on HFOV at PAW of 14 cmH2O (P start). PAW was increased stepwise to a maximum pressure (P max) and subsequently sequentially decreased to the closing pressure (Pcl, oxygenation deteriorated) or a minimum of 6 cmH2O, using an oxygenation-bas..

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Awarded by National Health and Medical Research Council Clinical Research Fellowship (Australia)

Funding Acknowledgements

D.G.T. is supported by a National Health and Medical Research Council Clinical Research Fellowship (Australia, grant ID 491286). D.G.T., E.J.P., and R.B. are supported by the Victorian Government Operational Infrastructure Support Program (Victoria, Australia). M.N. and M.L.V. are supported by a grant from Fondazione MBBM (Monza, Italy).