Journal article

Methylation of the SLC6a2 Gene Promoter in Major Depression and Panic Disorder

Richard Bayles, Emma K Baker, Jeremy BM Jowett, David Barton, Murray Esler, Assam El-Osta, Gavin Lambert

PLoS One | PUBLIC LIBRARY SCIENCE | Published : 2013


Reduced function of the noradrenaline transporter (NET) has been demonstrated in patients with major depressive disorder (MDD) and panic disorder. Attempts to explain NET dysfunction in MDD and panic disorder by genetic variation in the NET gene SLC6a2 have been inconclusive. Transcriptional silencing of the SLC6a2 gene may be an alternative mechanism which can lead to NET dysfunction independent of DNA sequence. The objective of this study was to characterise the DNA methylation state of the SLC6a2 gene promoter in patients with MDD and panic disorder. SLC6a2 promoter methylation was also analysed before and after antidepressant treatment. This study was performed with DNA from blood, using..

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Funding Acknowledgements

This work was supported by grants from the NHMRC. The Baker IDI Heart & Diabetes Institute is supported in part by the Victorian Government's OIS Program. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.