Interactive effect of Gm allotypes and HLA-B locus antigens on the human antibody response to a bacterial antigen

Abstract

200 healthy adults were immunized with 1 μg of the bacterial antigen monomeric flagellin from Salmonella adelaide, and grouped as responders and non-responders on the basis of a rise in titer of antibody 2 wk after immunization. Immunoglobulin allotypes G1m(a), G1m(z) and G3m(g) were more frequent among responders who made immunoglobulin (Ig) G antibody (P < 0.02), and HLA-B12 was more frequent among responders who made IgM antibody (P < 0.05). The mean log titer of IgG antibody was higher in females (P < 0.001), in subjects with G1m(a), G1m(z) and G3m(g) allotypes (P < 0.05), and in Gm heterozygotes (P < 0.01). The mean log titer of the IgG antibody response in subjects with particular Gm p..