Conference Proceedings

Propofol anaesthesia via target controlled infusion or manually controlled infusion: Effects on the bispectral index as a measure of anaesthetic depth

T Gale, K Leslie, M Kluger

Anaesthesia and Intensive Care | AUSTRALIAN SOC ANAESTHETISTS | Published : 2001


Target controlled infusions (TCI) of propofol allow anaesthetists to target constant blood concentrations and respond promptly to signs of inappropriate anaesthetic depth. Studies comparing propofol TCI with manually controlled infusion (MCI) reported similar control of anaesthesia, but did not use an objective measure of anaesthetic depth. We therefore tested whether the Bispectral Index (BIS), an electroencephalographic (EEG) variable, is more stable during propofol TCI or MCI. Forty patients received midazolam and fentanyl before induction and were randomized to TCI or MCI. Target propofol concentrations in the TCI group were 3 to 8 microg/ml. The MCI group received propofol bolus (approx..

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University of Melbourne Researchers