Journal article

Esmolol and anesthetic requirement for loss of responsiveness during propofol anesthesia

R Orme, K Leslie, A Umranikar, A Ugoni

Anesthesia & Analgesia | LIPPINCOTT WILLIAMS & WILKINS | Published : 2002

Abstract

UNLABELLED: The administration of esmolol decreases the propofol blood concentration, preventing movement after skin incision during propofol/morphine/nitrous oxide anesthesia. However, interaction with esmolol has not been tested when propofol is infused alone. Accordingly, we tested the hypothesis that esmolol decreases the propofol blood concentration, preventing response to command (CP50-awake) when propofol is infused alone in healthy patients presenting for minor surgery. With approval and consent, we studied 30 healthy patients, who were randomized to esmolol bolus (1 mg/kg) and then infusion (250 microg x kg(-1) x min(-1)) or placebo. Five minutes later, a target-controlled infusion ..

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University of Melbourne Researchers