Journal article
Aspirin in Patients Undergoing Noncardiac Surgery
PJ Devereaux, M Mrkobrada, DI Sessler, K Leslie, P Alonso-Coello, A Kurz, JC Villar, A Sigamani, BM Biccard, CS Meyhoff, JL Parlow, G Guyatt, A Robinson, AX Garg, RN Rodseth, F Botto, G Lurati Buse, D Xavier, MTV Chan, M Tiboni Show all
New England Journal of Medicine | MASSACHUSETTS MEDICAL SOC | Published : 2014
Abstract
BACKGROUND: There is substantial variability in the perioperative administration of aspirin in patients undergoing noncardiac surgery, both among patients who are already on an aspirin regimen and among those who are not. METHODS: Using a 2-by-2 factorial trial design, we randomly assigned 10,010 patients who were preparing to undergo noncardiac surgery and were at risk for vascular complications to receive aspirin or placebo and clonidine or placebo. The results of the aspirin trial are reported here. The patients were stratified according to whether they had not been taking aspirin before the study (initiation stratum, with 5628 patients) or they were already on an aspirin regimen (continu..
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Funding Acknowledgements
Supported by grants from the Canadian Institutes of Health Research, the National Health and Medical Research Council of Australia, and the Spanish Ministry of Health and Social Policy. Bayer Pharma provided the aspirin used in the study, and Boehringer Ingelheim provided the clonidine and some funding.