Book Chapter

Plasmacytoid Dendritic Cell Development

Ken Shortman, Priyanka Sathe, David Vremec, Shalin Naik, Meredith O'Keeffe

DEVELOPMENT AND FUNCTION OF MYELOID SUBSETS | Advances in Immunology | ELSEVIER ACADEMIC PRESS INC | Published : 2013

Abstract

Interferon-producing plasmacytoid dendritic cells (pDC) are a specialized branch of the dendritic cell (DC) family, and their differentiation in mice is closely linked to that of conventional DC (cDC). Several different developmental pathways retain the potential to form pDC and are likely to contribute to the steady-state pDC population. A lymphoid pathway to DC development produces mainly pDC as a branch otherwise leading to B-cell development; such pDC may carry relics of a lymphoid past such as DJ rearrangements of immunoglobulin heavy chain (IgH) genes. The myeloid pathway to pDC and cDC is better known, but recent reassessment has revealed several substreams of development with separat..

View full abstract