Journal article

Mice that are congenic for the char2 locus are susceptible to malaria

RA Burt, VM Marshall, J Wagglen, FR Rodda, D Senyschen, TM Baldwin, LA Buckingham, SJ Foote

Infection and Immunity | AMER SOC MICROBIOLOGY | Published : 2002


A major advance has been made towards the positional cloning of char2 (a quantitative trait locus encoding resistance to Plasmodium chabaudi malaria). Mice congenic for the locus have been used to fine map the gene and to prove that char2 plays a significant role in the outcome of malarial infection, independently of other resistance loci.