Interleukin-1 beta Produced in Response to Islet Autoantigen Presentation Differentiates T-Helper 17 Cells at the Expense of Regulatory T-Cells Implications for the Timing of Tolerizing Immunotherapy

Sebastien Bertin-Maghit; Dimeng Pang; Brendan O'Sullivan; Shannon Best; Emily Duggan; Sanjoy Paul; Helen Thomas; Thomas WH Kay; Leonard C Harrison; Raymond Steptoe; Ranjeny Thomas

Journal article

Interleukin-1 beta Produced in Response to Islet Autoantigen Presentation Differentiates T-Helper 17 Cells at the Expense of Regulatory T-Cells Implications for the Timing of Tolerizing Immunotherapy

Sebastien Bertin-Maghit, Dimeng Pang, Brendan O'Sullivan, Shannon Best, Emily Duggan, Sanjoy Paul, Helen Thomas, Thomas WH Kay, Leonard C Harrison, Raymond Steptoe, Ranjeny Thomas

Diabetes | AMER DIABETES ASSOC | Published : 2011

DOI: 10.2337/db10-0104

University of Melbourne Researchers

Leonard Harrison Author Medical Biology (W.E.H.I.)

Grants

Awarded by National Health and Medical Research Council (NHMRC)

Awarded by Juvenile Diabetes Research Foundation

Funding Acknowledgements

This work was supported by National Health and Medical Research Council (NHMRC) grants 351439 and 569938 and Juvenile Diabetes Research Foundation grants 1-2006-149 and 5-2003-269. R.T. was supported by Arthritis Queensland and an Australian Research Council Future Fellowship. R.S. was supported by an NHMRC Career Development Award. B.O. was supported by a Queensland Smart State Fellowship.