Journal article
The addition of tramadol to the standard of IV acetaminophen and morphine infusion for postoperative analgesia in neonates offers no clinical benefit: a randomized placebo-controlled trial
Monika Olischar, Greta M Palmer, Francesca Orsini, Andrew J Davidson, Elizabeth J Perkins, Katherine J Lee, Neil J Everest, Noel E Cranswick, Rod W Hunt
Pediatric Anesthesia | WILEY | Published : 2014
DOI: 10.1111/pan.12477
Abstract
BACKGROUND: Tramadol is used following neonatal cardiac and general surgery. However, its ability to opioid-spare or facilitate earlier extubation in postoperative neonates is unquantified. OBJECTIVE: This randomized placebo-controlled trial aimed to assess whether tramadol's addition to standard analgesia resulted in earlier extubation or reduced analgesic/sedative requirements in postsurgical neonates. METHODS: Neonates born ≥32 weeks postmenstrual age received either tramadol [T] 2 mg·kg(-1) or placebo [P] 6-hourly for up to 5 days postthoracoabdominal surgery in addition to morphine (commenced at 20 mcg·kg(-1) ·h(-1)) and 6-hourly i.v. acetaminophen. Time to extubation, morphine and mida..
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Funding Acknowledgements
A small project grant from the Murdoch Childrens Research Institute funded the preparation of drugs. No other funding was secured for this study. The authors have no financial disclosures to make relevant to this article.