Journal article

Diagnosis of pulmonary tuberculosis in children in an HIV-endemic area, Malawi

J Kiwanuka, SM Graham, JBS Coulter, JS Gondwe, N Chilewani, H Carty, CA Hart

Paediatrics and International Child Health | CARFAX PUBLISHING | Published : 2001


The diagnosis of pulmonary tuberculosis (PTB) in young children is particularly complex in resource-poor regions where HIV infection is common. This study examines the impact of HIV infection on diagnosis in children with suspected PTB attending Queen Elizabeth Central Hospital, Blantyre. A total of 110 children (4 months-14 years) were studied over a 4-month period. Clinical data were recorded and investigations included Mantoux test, chest X-ray, HIV status (HIV-PCR when younger than 18 months) and sputum, if available. Laryngeal swabs were compared with sputa or gastric aspirates in a subgroup of 60 children. All children were commenced on anti-TB therapy and followed for treatment respon..

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