Journal article

Multiple Infections with Seasonal Influenza A Virus Induce Cross-Protective Immunity against A(H1N1) Pandemic Influenza Virus in a Ferret Model

Karen L Laurie, Louise A Carolan, Deborah Middleton, Sue Lowther, Anne Kelso, Ian G Barr

JOURNAL OF INFECTIOUS DISEASES | OXFORD UNIV PRESS INC | Published : 2010

Abstract

BACKGROUND: An age bias toward children and young adults has been reported for infection and hospitalizations with pandemic H1N1 influenza (A[H1N1]pdm) in the 2009 and 2010 influenza seasons in the Southern and Northern Hemispheres. Serological analysis of prepandemic samples has shown a higher incidence of cross-reactive antibodies to A(H1N1)pdm virus in older populations; conserved T cell epitopes between viruses have been identified. The contribution of preexisting immunity to seasonal influenza to protection against A(H1N1)pdm infection was analyzed in a ferret model. METHODS: Ferrets were pre-infected with influenza A viruses and/or vaccinated with inactivated influenza viruses with adj..

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University of Melbourne Researchers