Journal article

CD26 (dipeptidyl-peptidase IV)-dependent recruitment of T cells in a rat asthma model

C Kruschinski, T Skripuletz, S Bedoui, T Tschernig, R Pabst, C Nassenstein, A Braun, S von Horsten

Clinical & Experimental Immunology | WILEY | Published : 2005

Abstract

CD26 truncates several chemokines as well as neuropeptides and influences immune responses via modulation of cell adhesion and T cell activation, suggesting an involvement of CD26 in asthmatic and airway inflammation. Therefore, Fischer 344 (F344), Brown Norway (BN) and Lewis (LEW) rat strains, which differ in their CD26-like enzymatic activity, were compared using an asthma model. Additionally, two CD26-deficient mutant F344 rat substrains were included and compared to the wild-type F344 substrain. Immunization was performed twice with ovalbumin (OVA), and 2 weeks later the rats were challenged with OVA intratracheally Flow cytometry (FACS) analysis of different leucocyte subsets as well as..

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University of Melbourne Researchers